CellRenew STS Supplement Facts and Monograph

CellRenew STS Defined

CellRenew STS Hydrolyzed Type II Collagen Soft Tissue Support

CellRenew STS contains 1000 milligrams of Biocell Hydrolyzed Collagen Type II, derived from the ONLY patented process for producing nature's full-spectrum joint support formula.

CellRenew STS provides multi-dimensional nutritional components useful in maintaining and improving connective soft tissue (joints, skin, cardiovascualr, etc.). Naturally-occurring nutritional co-factors (Hyaluronic Acid, Chondroitin Sulfate, Glucosamine, and other collagen proteins) offer regenerative anti-aging benefits that support joint-cushion, lubrication, and mobility.

Since 1997, we have supplied discriminating customers and doctors, who accept no compromises. CellRenew STS defines the ultimate collagen product by containing 1000 milligrams of the most advance collagen type II in every dose.

If you demand results from your joint support product, reach for the one that has proven itself for almost 20 years.

Reach for CellRenew STS from Applied Health.
 
For more information on CellRenew Collagen Type II, Click Here


Supplement Facts
Serving Size: 2 capsules
Servings per Container: 30

Amount Per Serving % Daily Value

BioCell Collagen II
(Chicken Collagen Type II)
Chondroitin Sulfate 200 mg
Hyaluronic Acid 100 mg
1000 mg *

* Daily value not established

Other Ingredients: Vegetarian capsule (hydroxypropyl methylcellulose, water).

Suggested Use
2 capsules each morning, on an empty stomach, with some form of vitamin C (e.g.: orange juice or supplement). For best results, wait at least 20 minutes before consuming any food or other drink, allowing time for the CellRenew STS to digest and get into the bloodstream.
Suggested Use
As a dietary supplement take four (4) capsules in the morning on an empty stomach, or as directed by a healthcare practitioner.

CellRenew Monograph

Description

CellRenew contains Hydrolyzed Collagen Type II derived from 100% pure chicken sternal cartilage. As an abundant source of naturally-occurring Hyaluronic Acid and Chondroitin Sulfates, Collagen Type II is easily absorbed to restore joint and cartilage health. CellRenew is produced in the United States through a patented process to deliver the highest-quality standards for safe, effective supplementation.

Overview

Feel revitalized with a product designed to support joint function, plus renew healthy skin, hair and nails. CellRenew is an abundant source of Hyaluronic Acid and Chondroitin Sulfates. It is an absorbable hydrolyzed collagen type II product derived from 100% pure chicken sternal cartilage that strengthens cartilage, relieves joint discomfort and increases mobility. CellRenew naturally contains the key “beauty” substance, hyaluronic acid that can repair skin by boosting hydration and elasticity, while reducing the appearance of fine lines and wrinkles.

Research

Collagen Type II:

Along with the natural components of Hyaluronic Acid and Chondroitin Sulfates, Collagen Type II (CCII) contains cartilage glycoproteins that boost antioxidant protection in the joints. CCII’s properties can suppress pro-inflammatory activity to reduce joint discomfort and restore cartilage health.1 CCII from chicken sternal cartilage was shown to reduce chronic joint inflammation by helping to regulate humoral and cellular immune systems. 2,3

A three-month study recruited 60 patients with chronic joint inflammation to take CCII or a placebo. Results indicated CCII alleviated swollen and tender joints in the treatment group. Four patients in the treatment group had a complete remission of chronic joint inflammation.4

A twelve-week study recruited 24 patients with chronic joint inflammation to take Collagen Type II. Results indicated 90% of patients experienced improvement in joint health, without side effects.5 Similarly, a pilot-study recruited female subjects with joint pain to take Hydrolyzed Collagen Type II for 42 days. Subjects reported a significant improvement in joint mobility and decrease in joint pain and stiffness.6

CCII is evidenced to be effective among adolescents with chronic joint inflammation. A pilot-study administered CCII to 10 adolescent patients with chronic joint inflammation for 12 weeks. Eight patients experienced a reduction in swollen and tender joints. CCII was well-tolerated by all subjects.7 A similar pilot-study recruited nine adolescents with chronic joint inflammation to take an oral Collagen Type II, finding the supplement was well-tolerated and reduced joint inflammation.8

An animal study found that CCII improved immune balance to help regulate the production of helper T cells.9

Chondroitin Sulfate (Component of Collagen Type II)

Naturally found in sternal chicken Collagen Type II, chondroitin sulfate has anti-inflammatory activity that reduces joint swelling, maintains synovial fluid levels, and spacing between the joints.10 Furthermore, chondroitin sulfate reduces the proliferation of proteins to reduce joint inflammation.11

A one-year study recruited 42 patients with knee pain to take chondroitin sulfate or a placebo. Subjects taking chondroitin sulfate had greater joint mobility and less pain, when compared to the placebo group. Researchers suggested chondroitin sulfate could stabilize joint space, while improving bone and joint metabolism.12

A three-month study recruited 110 patients with knee pain to take chondroitin sulfate or a placebo finding supplementation improved knee function, reduced pain, and maintained joint space in the knee.13

One study found that cartilage cells responded to chondroitin sulfate and glucosamine when joints were under stress in aged-animals. Researchers suggested chondroitin sulfate and glucosamine could repair and regenerate cartilage by supporting normal metabolic function in the joints.14

Hyaluronic Acid (Component of Collagen Type II)

Hyaluronic acid (HA) is a natural component of sternal chicken Collagen Type II. HA is also found in human cartilage, skin collagen, and synovial fluid. Unfortunately, optimum amounts diminish with age leading to weaker joints and aging skin.15

Studies have suggested hyaluronic acid has anti-inflammatory activity that suppresses pro-inflammatory and pain mechanisms in the body.16

A twelve-month study compared the effects of HA with an exercise therapy among 30 patients with ankle inflammation and pain. Researchers found that both the HA and exercise therapy groups had functional improvement in their ankle joints, suggesting both therapies are beneficial in treating joint discomfort.17

Researchers found that HA inhibited inflammatory cytokine activity in mice with inflamed joints.18 A similar study reviewed the effects of HA on acute and chronic inflammation in rats, finding HA suppressed inflammatory reactions to aid healthy cartilage production.19

Furthermore, HA is a natural moisturizer found in skin collagen that is commonly used in skincare procedures.20 Restoring HA can improve protein-binding activity and enhance tissue production to deter the effects of aging skin.21,11

Additional Information – Dosage & Interactions

Suggested Use

As a dietary supplement, take four capsules daily on an empty stomach, or as directed by a physician.

Dosage

Collagen Type II – 1,000 mg per day

Chondroitin Sulfate – Up to 1,200 mg per day in divided doses

Hyaluronic Acid –No typical dosage

Precautions

The maximum safe dosages of the nutrients in this formula have not been determined for children, pregnant or nursing women, or those with severe liver or kidney disease. As with all supplement regimens, please consult your physician prior to use.

Chondroitin Sulfate - Mild gastrointestinal upset has been reported, such as nausea and diarrhea.
Collagen Type II - There are no known adverse reactions with proper supplementation.
Hyaluronic Acid - There are no known adverse reactions with proper supplementation.

Drug Interactions

Consult a physician before taking CellRenew, as the following key nutrients may interact with certain medications.

Chondroitin Sulfate – There are no known interactions with proper supplementation.

Collagen Type II - There are no known interactions with proper supplementation.

Hyaluronic Acid –There are no known interactions with proper supplementation.

*Statements made herein have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

References:
1 Garcia G, Komagata Y, Slavin A, Maron R, Weiner H. Suppression of collagen-induced arthritis by oral or nasal administration of type II collagen. J of Autoimmunity. 1999; 13(3): 315-324.

2 Caoa H, Xub S, Gec H, Xua F. Molecular characterisation of type II collagen from chick sternal cartilage and its anti-rheumatoid arthritis activity. Food and Agricul Immuno. 2013 Jan 9.

3 Su Z, Shotorbani SS, Jiang X, et al. A method of experimental rheumatoid arthritis induction using collagen type II isolated from chicken sternal cartilage. Mol Med Rep. 2013 Jul;8(1):113-7.

4 Trentham DE, Dynesius-Trentham RA, Orav EJ, Combitchi D. Effects of oral administration of type II collagen on rheumatoid arthritis. Science. 1993; 261(5129):1727-1730.

5 Ausar S, Beltramo D, Castagna L, Quintana S, et al. Treatment of rheumatoid arthritis by oral administration of bovine tracheal type II collagen. Rheumat Intern. 2001; 20(4):138-144.

6 Bagchi D, Misner B, Bagchi M, Kothari SC, et al. Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. Int J Clin Pharmacol Res. 2002; 22(3-4):101-110.

7 Barnett M, Combitchi D, Trentham D. A pilot trial of oral type II collagen in the treatment of juvenile rheumatoid arthritis. Arthritis Rheum. 1996; 39:623-628.

8 Myers LK, Higgins GC, Finkel TH, Reed AM, et al. Juvenile arthritis and autoimmunity to type II collagen. Arthritis & Rheum. 2001; 44(8):1775-1781.

9 Tong T, Zhao W, Wu YQ, et al. Chicken type II collagen induced immune balance of main subtype of helper T cells in mesenteric lymph node lymphocytes in rats with collagen-induced arthritis. Inflamm Res. 2010 May;59(5):369-77.

10 Iovu M, Dumais G, Du Souich P. Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis Cartilage. 2008 Jul 28.

11 Jomphe C, Gabriac M, Hale TM, et al. Chondroitin sulfate inhibits the nuclear translocation of nuclear factor-kappaB in interleukin-1beta-stimulated chondrocytes. Basic Clin Pharmacol Toxicol. 2008; 102(1):59-65.

12 Uebelhart D, Thonar EJ, Delmas PD, et al. Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study. Osteoarthritis Cartilage. 1998; 6(A):39-46.

13 Uebelhart D, Malaise M, Marcolongo R, et al. Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a one-year, randomized, double-blind, multicenter study versus placebo. Osteoarthritis Cartilage. 2004; 12(4):269-276.

14 Lippiello L. Glucosamine and chondroitin sulfate: biological response modifiers of chondrocytes under simulated conditions of joint stress. Osteoarthritis Cartilage. 2003; 11(5):335-342.

15 Ghersetich I, Lotti T. Hyaluronic acid in cutaneous intrinsic aging. Int J Dermatol, 1994; 33:119-122.

16 Ghosh P. The role of hyaluronic acid (hyaluronan) in health and disease: interactions with cells, cartilage and components of synovial fluid. Clin and Exper Rheumat. 1994; 12:75-82.

17 Karatosun V, Unver B, Ozden A, Ozay Z, Gunal I. Intra-articular hyaluronic acid compared to exercise therapy in osteoarthritis of the ankle. A prospective randomized trial with long-term follow-up. Clin Exp Rheumatol. 2008; 26(2):288-294.

18 Zhou PH, Liu SQ, Peng H. The effect of hyaluronic acid on IL-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis. J Orthop Res. 2008 Jun 3.

19 Ialenti A, Di Rosa M. Hyaluronic acid modulates acute and chronic inflammation. Inflammation Research. 1994; 43(1-2):44-47.

20 Pomarede N. Hyaluronic Acid. Ann Dermatol Venereol. 2008; 135(1-2):1S35-1S38.

21 Meyer LJ, Stern,R. Age-dependent changes of hyaluronan in human skin. J Invest Dermatol. 1994; 102:385-389.